TRANSFORMING RNA-SEQ GENE EXPRESSION TO TRACK CANCER PROGRESSION IN THE MULTI-STAGE EARLY TO ADVANCED-STAGE CANCER DEVELOPMENT.

Transforming RNA-Seq gene expression to track cancer progression in the multi-stage early to advanced-stage cancer development.

BackgroundCancer progression can be tracked by gene expression changes that occur throughout early-stage to advanced-stage cancer development.The accumulated genetic changes can be detected when gene expression levels in advanced-stage are less variable but show high variability in early-stage.Normalizing advanced-stage expression samples with earl

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Identification and Validation of an Immune Evasion Molecular Subgroup of Patients With Colon Cancer for Implications of Immunotherapy

Immune evasion (IEV) plays a critical role in the development and progression of colon cancer.However, studies to predict the prognosis of colon cancer via IEV-related genes are limited.Therefore, based on the 182 IEV-related genes, we used the univariate and Lasso Cox regression model to construct the IEV-related genes signature (IEVSig) of 16 pro

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Experimental investigation on calcium dissolution performance of shotcrete with different waterproofing agents

The crystalline blockage of tunnel drainage pipes poses a common challenge to tunnel engineering, particularly in regions with abundant groundwater and severe ion erosion.Based on the design of concrete mix proportion, this paper improves the calcium ion erosion resistance of shotcrete by adding permeable crystalline sodium methyl silicate waterpro

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Rab3D is critical for secretory granule maturation in PC12 cells.

Neuropeptide- and hormone-containing secretory granules (SGs) are synthesized at the trans-Golgi network (TGN) as immature secretory granules (ISGs) usadisk website and complete their maturation in the F-actin-rich cell cortex.This maturation process is characterized by acidification-dependent processing of cargo proteins, condensation of the SG ma

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